diff --git a/content/browser/web_contents/web_contents_impl.cc b/content/browser/web_contents/web_contents_impl.cc
index c63728f12f6488e79d864af81c0637ef58d2dd40..28198a0dc3d8a9d39416120976f62b29959f96b0 100644
--- a/content/browser/web_contents/web_contents_impl.cc
+++ b/content/browser/web_contents/web_contents_impl.cc
@@ -4198,6 +4198,16 @@ void WebContentsImpl::ShowCreatedWindow(RenderFrameHostImpl* opener,
   if (!owned_created || !owned_created->contents)
     return;
 
+  if (active_file_chooser_) {
+    // Do not allow opening a new window or tab while a file select is active
+    // file chooser to avoid user confusion over which tab triggered the file
+    // chooser.
+    opener->AddMessageToConsole(
+        blink::mojom::ConsoleMessageLevel::kWarning,
+        "window.open blocked due to active file chooser.");
+    return;
+  }
+
   WebContentsImpl* created = owned_created->contents.get();
 
   // This uses the delegate for the WebContents where the window was created