diff --git a/runtime/main/page/api/Differ.ts b/runtime/main/page/api/Differ.ts
index 1726b6130657b56c60f4c364e9c05710040e963a..c40314ab3a454686eeb1b9b0724ca7f9b8c0e076 100644
--- a/runtime/main/page/api/Differ.ts
+++ b/runtime/main/page/api/Differ.ts
@@ -63,10 +63,13 @@ export default class Differ {
       this._hasTimer = true;
 
       // Use setTimeout instead of setTimeoutDiffer
-      setTimeout(() => {
-        this._hasTimer = false;
-        this.flush();
-      }, 0);
+      // avoid invoking setTimeout after appDestroy
+      if (typeof setTimeout === "function") {
+        setTimeout(() => {
+          this._hasTimer = false;
+          this.flush();
+        }, 0);
+      }
     }
     const map: object[] = this._map;
     if (!map[defaultDepth]) {