diff --git a/cufflinks.spec b/cufflinks.spec
index 9a3ad176c1683c15822e771b608facf41b2d50b3..774e9fbb30e180fc74749eb2ef33c693f09c8402 100644
--- a/cufflinks.spec
+++ b/cufflinks.spec
@@ -1,6 +1,6 @@
 Name:           cufflinks
 Version:        2.2.1
-Release:        1
+Release:        2
 Summary:        Transcriptome assembly and differential expression analysis for RNA-Seq.
 
 License:        GPL-3.0-only and BSL-1.0
@@ -15,6 +15,7 @@ Patch4:         0005-fix_no_hash_member.patch
 Patch5:         0006-format-security.patch
 Patch6:         0007-py2to3.patch
 Patch7:         0008-boost_bind_header.patch
+Patch8:         multiple-definition-linker-error.patch
 
 BuildRequires:  boost boost-serialization boost-system boost-thread boost-devel samtools samtools-devel htslib htslib-devel
 BuildRequires:  gcc gcc-c++ gcc-gfortran make autoconf gmp mpfr openmpi java-1.8.0-openjdk-headless
@@ -61,5 +62,8 @@ find %{buildroot}/%{_bindir}/ -type f -name gffread -delete
 
 
 %changelog
+* Sat Aug 07 2021 wangyue <wangyue92@huawei.com> - 2.2.1-2
+- Fix FTBFS with GCC 10
+
 * Wed Mar 24 2021 He Rengui <herengui@uniontech.com> - 2.2.1-1
 - Package init
diff --git a/multiple-definition-linker-error.patch b/multiple-definition-linker-error.patch
new file mode 100644
index 0000000000000000000000000000000000000000..165a978a36257aff140e0abfd290bbf95f608b87
--- /dev/null
+++ b/multiple-definition-linker-error.patch
@@ -0,0 +1,24 @@
+From 8e89c64b095d114414a71d0eb62358c3bc21fd7e Mon Sep 17 00:00:00 2001
+Author: Reiner Herrmann <reiner@reiner-h.de>
+Description: Fix FTBFS with GCC 10 curwin is declared in different source file. declare it as extern to fix multiple definition linker error.
+
+---
+ src/locfit/startlf.c | 2 +-
+ 1 file changed, 1 insertion(+), 1 deletion(-)
+
+diff --git a/src/locfit/startlf.c b/src/locfit/startlf.c
+index 6255410..f5435f7 100644
+--- a/src/locfit/startlf.c
++++ b/src/locfit/startlf.c
+@@ -233,7 +233,7 @@ INT (*vfun)(), nopc;
+ extern lfit lf;
+ extern design des;
+ extern plots pl[];
+-int curwin;
++extern int curwin;
+ vari *vb;
+ 
+ INT nofit()
+-- 
+2.23.0
+